The Patient Identifier Cross-referencing (PIX) Integration Profile is part if the IHE IT Infrastructure technical framework.

This profile is targeted at healthcare enterprises of a broad range of sizes (hospital, a clinic, a physician office, etc.). It supports the cross-referencing of patient identifiers from multiple Patient Identifier Domains via the following interactions:

• The transmission of patient identity information from an identity source to the Patient Identifier Cross-reference Manager.
• The ability to access the list(s) of cross-referenced patient identifiers either via a query/ response or via update notification.

By specifying the above transactions among specific actors, this profile does not define any specific enterprise policies or cross-referencing algorithms. By encapsulating these behaviors in a single actor, this profile provides the necessary interoperability while maintaining the flexibility to be used with any cross-referencing policy and algorithm as deemed adequate by the enterprise.

Source: IHE IT Infrastructure Technical Framework rev 5.1